?Sherlock Holmes took his bottle from the corner of the mantelpiece, and his hypodermic syringe from its neat morocco case. With his long, white, nervous fingers he adjusted the delicate needle and rolled back his left shirtcuff...?
The Sign of the Four (1890), also called The Sign of Four, is the second novel featuring Sherlock Holmes written by Sir Arthur Conan Doyle. Doyle wrote four novels and 56 stories starring the fictional detective.
The story is set in 1888. The Sign of Four has a complex plot involving service in East India Company, India, the Indian Rebellion of 1857, a stolen treasure, and a secret pact among four convicts ("the Four" of the title) and two corrupt prison guards. It presents the detective's drug habit and humanizes him in a way that had not been done in the preceding novel, A Study in Scarlet (1887). It also introduces Doctor Watson's future wife, Mary Morstan.
As with the first story, A Study in Scarlet, produced two years previously, The Sign of Four was not particularly successful to start with.